PHARMACEUTICAL BREAKTHROUGHS

ISSN NO : 2996-1157

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Umbilical Cord Stem Cell Stem Cell Therapy For Rare Genetic Disease Prader-Willi Syndrome

1 Cell Tech Stem Cell Centre Laboratory & Banking, Jakarta,Indonesia

Volume 1

Issue 1

Page: [8 - 16]

Published Online: November 10, 2023

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  • Abstract

    • This Abstract Summarises The Studies On The Use Of Umbilical Cord Stem Cells To Treat Prader-Willi Syn- Drome. Among The Various Stem Cells Found In The Umbilical Cord, Hematopoietic And Mesenchymal Stem Cells May Create Bioactive Molecules That Aid In Tissue Repair And Regeneration, Control Immunological Responses, And Give Birth To A Variety Of Cell Types. Because Of This, They Present A Feasible Option For Treating The Multidisciplinary Character Of PWS. Preclinical Research On PWS Animal Models Has Shown Promising Outcomes, With Umbilical Cord Stem Cell Transplantation Improving Metabolic Disorders, Hy- Pothalamic Function, And General Behavior. It Has Been Investigated If Immunological Regulation, Trophic Support, And Paracrine Signaling Are Among The Factors That Promote Stem Cell Therapeutic Potential. Several Clinical Studies Employing Umbilical Cord Stem Cells To Treat PWS Are Now Underway, And The Findings Should Aid In Assessing The Advantages And Disadvantages Of Using This Approach On Patients. The Preliminary Evidence Is Encouraging, Since Some Trial Participants Improved In Hyperphagia, Mus- Cular Tone, And Cognitive Ability. Although The Use Of Umbilical Cord Stem Cells As A PWS Treatment Has Shown Some Promise, Further Study Is Required To Determine Its Long-Term Safety, Optimal Dose, And Ongoing Effectiveness. A Variety Of Key Elements, Such As Ethical Issues, Regulatory Frameworks, And The Availability Of Standardized Stem Cell Products, Will Have A Considerable Impact On The Future Development Of This Treatment Technique. SD Is A Disease Known As A Neurodevelopmental Problem Represented Through Problems With Social Communication, Sensor Sensitivity, And Repetitive Behaviors. Despite Years Of Study, Therapy Options For Autism Spectrum Disorder (ASD) Remain Relatively Limited. As Regenerative Medicine Has Improved, Stem Cell Treatment Has Been Investigated As A Novel Thera- Peutic Option For The Underlying Neurological Disorders That Underpin ASD. The Development, Possible Methods, And Potential Uses Of Stem Cell Treatment For Autistic Children Are Discussed In This Article.

    Keywords: Prader-Willi Syndrome Umbilical Cord Stem Cells Stem Cell Therapy Genetic Disorder Multi-Systemic Improvements Preclinical Studies Clinical Trials Hypothalamic Function Behavioral Manifestations

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      • [1] Adam, M., & Hussain, N. (2017). Impact of celebrity endorsement on consumers buying behavior. British Journal of Marketing Studies, 5(3), 79–121
      • [2] Ahmad, I. (2018). The Influencer Marketing Revolution [Infographic]. Social Media Today. https://www.socialmediatoday.com/news/t he-influencer-marketing-revolution- infographic/517146/
      • [3] Ajzen, I. (1989). Attitude structure and behavior. Attitude structure and function. Edt. Pratkanis AR
      • [4] Ajzen, I., & Cote, N. G. (2008). Attitudes and the prediction of behavior. Attitudes and Attitude Change, 13
      • [5] Akar, E., & Topçu, B. (2011). An examination of the factors influencing consumers’ attitudes toward social media marketing. Journal of Internet Commerce, 10(1), 35–67
      • [6] Akbar, W., Hassan, S., Khurshid, S., Niaz, M., & Rizwan, M. (2014). Antecedents Affecting Customer’s Purchase Intentions towards Green Products. Journal of Sociological Research, 5(1). https://doi.org/10.5296/jsr.v5i1.6566
      • [7] Al-Dhuhli, I., & Ismael, S. (2013). The Impact of social media on consumer buying behaviour. Unpublished Master’s Project, Sultan Qaboos University
      • [8] Arcury, T. (1990). Environmental Attitude and Environmental Knowledge. Human Organization, 49(4), 300–304. https://doi.org/10.17730/humo.49.4.y6135 676n433r880
      • [9] Arnould, E. J., & Thompson, C. J. (2005). Consumer Culture Theory (CCT): Twenty Years of Research. Journal of Consumer Research, 31(4), 868–882. https://doi.org/10.1086/426626
      • [10] Asha, P., & Rathiha, R. (n.d.). CONSUMER AWARENESS TOWARDS GREEN PRODUCTS
      • [11] Awuni, J. A., Du, J., & Yiranbon, E. (2016). Factors influencing green purchasing behaviors: Some insights from Tamale, Ghana. British Journal of Economics, Management & Trade, 14(4), 1–12
      • [12] Berger, J., & Keller, F. (2016). Research shows Micro-Influencers have more impact than average consumers. Research Shows Micro Influencers Have More Impact than Average Consumers, 1–3
      • [13] Brown, D., & Hayes, N. (2008). Influencer marketing: Who really influences your customers? Elsevier/Butterworth- Heinemann
      • [14] Chan, R. Y. K., & Lau, L. B. Y. (2002). Explaining Green Purchasing Behavior: A Cross-Cultural Study on American and Chinese Consumers. Journal of International Consumer Marketing, 14(2–3), 9–40. https://doi.org/10.1300/J046v14n02_02
      • [15] Chen, K., & Deng, T. (2016). Research on the Green Purchase Intentions from the Perspective of Product Knowledge. Sustainability, 8(9), 943. https://doi.org/10.3390/su8090943
      • [16] Cherian, J., & Jacob, J. (2012). Green Marketing: A Study of Consumers’ Attitude towards Environment Friendly Products. Asian Social Science, 8(12), p117. https://doi.org/10.5539/ass.v8n12p117
      • [17] Chu, K. M. (2018). Mediating influences of attitude on internal and external factors influencing consumers’ intention to purchase organic foods in China. Sustainability, 10(12), 4690
      • [18] Chuang, S.-P., & Huang, S.-J. (2018). The Effect of Environmental Corporate Social Responsibility on Environmental Performance and Business Competitiveness: The Mediation of Green Information Technology Capital. Journal of Business Ethics, 150(4), 991–1009. https://doi.org/10.1007/s10551- 016-3167-x
      • [19] Chukwu, B. A., & Enudu, T. O. (n.d.). CONSUMERS’ PURCHASING BEHAVIOR IN
      • [20] Debora Indriani, I. A., Rahayu, M., & Hadiwidjojo, D. (2019). The Influence of Environmental Knowledge on Green Purchase Intention the Role of Attitude as Mediating Variable. International Journal of Multicultural and Multireligious Understanding, 6(2), 627. https://doi.org/10.18415/ijmmu.v6i2.706
      • [21] Djafarova, E., & Rushworth, C. (2017). Exploring the credibility of online celebrities’ Instagram profiles in influencing the purchase decisions of young female users. Computers in Human Behavior, 68, 1–7. https://doi.org/10.1016/j.chb.2016.11.009
      • [22] Doszhanov, A., & Ahmad, Z. A. (2015). Customers’ Intention to Use Green Products: The Impact of Green Brand Dimensions and Green Perceived Value. SHS Web of Conferences, 18, 01008. https://doi.org/10.1051/shsconf/201518010 08
      • [23] Dunlap, R. E., & Van Liere, K. D. (1978). The “New Environmental Paradigm.” The Journal of Environmental Education, 9(4), 10–19. https://doi.org/10.1080/00958964.1978.10 801875
      • [24] Dunlap, R., & Jones, R. (2002). Environmental Concern: Conceptual and Measurement Issues. 484–524
      • [25] Fromm, J. (2018). How Much Financial Influence Does Gen Z Have? Forbes. https://www.forbes.com/sites/jefffromm/20 18/01/10/what-you-need-to-know-about- the-financial-impact-of-gen-z-influence/
      • [26] Fryxell, G. E., & Lo, C. W. H. (2003). The Influence of Environmental Knowledge and Values on Managerial Behaviours on Behalf of the Environment: An Empirical Examination of Managers in China. Journal of Business Ethics, 46(1), 45–69. https://doi.org/10.1023/A:1024773012398
      • [27] Ghazali, E. M., Mutum, D. S., & Ariswibowo, N. (2018). Impact of religious values and habit on an extended green purchase behaviour model. International Journal of Consumer Studies, 42(6), 639– 654. https://doi.org/10.1111/ijcs.12472
      • [28] Granzin, K. L., & Olsen, J. E. (1991). Characterizing Participants in Activities Protecting the Environment: A Focus on Donating, Recycling, and Conservation Behaviors. Journal of Public Policy & Marketing, 10(2), 1–27. https://doi.org/10.1177/074391569101000 201
      • [29] Gremm, J., Barth, J., Fietkiewicz, K. J., & Stock, W. G. (2017). Transitioning Towards a Knowledge Society: Qatar as a Case Study. Springer
      • [30] Hair, J. F. (Ed.). (2010). Multivariate data analysis (7th ed). Prentice Hall
      • [31] Hasnah Hassan, S. (2014). The role of Islamic values on green purchase intention. Journal of Islamic Marketing, 5(3), 379–395. https://doi.org/10.1108/JIMA-11-2013- 0080
      • [32] Hassan, A. S., & Witchayangkoon, B. (2019). Articles in ITJEMAST 10 (17) 2019. International Transaction Journal of Engineering, Management, & Applied ....
      • [33] Hoffower, H. (2020). Gen Z is set to take over the economy in a decade, despite potentially losing $10 trillion in earnings because of the pandemic. Business Insider. https://www.businessinsider.com/gen-z- will-take-over-economy-2030-33-trillion- income-2020-11
      • [34] Jalali, S. S., & Khalid, H. B. (2021). The Influence of Instagram Influencers’ Activity on Green Consumption Behavior. Business Management and Strategy, 12(1), 78–90
      • [35] Johansen, I. K., & Guldvik, C. S. (2017). Influencer marketing and purchase intentions: How does influencer marketing affect purchase intentions? [Master’s Thesis]
      • [36] Kaiser, F. G., Wölfing, S., & Fuhrer, U. (1999). ENVIRONMENTAL ATTITUDE AND ECOLOGICAL BEHAVIOUR. Journal of Environmental Psychology, 19(1), 1–19. https://doi.org/10.1006/jevp.1998.0107
      • [37] Kale, E. (n.d.). Influencer Marketing in Circular Economy
      • [38] Kaufmann, H. R., Panni, M. F. A. K., & Orphanidou, Y. (2012). Factors Affecting Consumers’ Green Purchasing Behavior: An Integrated Conceptual Framework. Amfiteatru Economic, 31
      • [39] Kong, W., Harun, A., Sulong, R. S., & Lily, J. (2014). The Influence of Consumers Perception of Green Products on Green Purchase Intention. International Journal of Asian Social Science, 4(8), Article 8
      • [40] Kotler, P., & Keller, K. L. (2012). Marketing management (14th [ed.]). Prentice Hall
      • [41] Liu, M. T., Liu, Y., & Mo, Z. (2020). Moral norm is the key: An extension of the theory of planned behaviour (TPB) on Chinese consumers’ green purchase intention. Asia Pacific Journal of Marketing and Logistics, 32(8), 1823–1841. https://doi.org/10.1108/APJML-05-2019- 0285
      • [42] Milfont, T. L. (2012). The Psychology of Environmental Attitudes: Conceptual and Empirical Insights from New Zealand. Ecopsychology, 4(4), 269–276. https://doi.org/10.1089/eco.2012.0058
      • [43] Nduneseokwu, C. K., Qu, Y., & Appolloni, A. (2017). Factors Influencing Consumers’ Intentions to Participate in a Formal E-Waste Collection System: A Case Study of Onitsha, Nigeria. Sustainability, 9(6), Article 6. https://doi.org/10.3390/su9060881
      • [44] Nov, O., Naaman, M., & Ye, C. (2008). What drives content tagging: The case of photos on Flickr. Proceeding of the Twenty- Sixth Annual CHI Conference on Human Factors in Computing Systems - CHI ’08, 1097. https://doi.org/10.1145/1357054.1357225
      • [45] Paul, J., Modi, A., & Patel, J. (2016). Predicting green product consumption using theory of planned behavior and reasoned action. Journal of Retailing and Consumer Services, 29, 123–134. https://doi.org/10.1016/j.jretconser.2015.1 1.006
      • [46] Polonsky, M. J. (1994). An Introduction To Green Marketing. Electronic Green Journal, 1(2). https://doi.org/10.5070/G31210177
      • [47] Pride, W. M., & Ferrell, O. C. (1993). Marketing: Study Guide, 1993. Houghton Mifflin School
      • [48] Quansah, F., Okoe, A., & Angenu, B. (2015). Factors Affecting Ghanaian Consumers’ Purchasing Decision of Bottled Water. International Journal of Marketing Studies, 7(5), p76. https://doi.org/10.5539/ijms.v7n5p76
      • [49] Ramsey, C. E., & Rickson, R. E. (1976). Environmental Knowledge and Attitudes. The Journal of Environmental Education, 8(1), 10–18. https://doi.org/10.1080/00958964.1976.99 41552
      • [50] Rusyani, E., Lavuri, R., & Gunardi, A. (2021). Purchasing Eco-Sustainable Products: Interrelationship between Environmental Knowledge, Environmental Concern, Green Attitude, and Perceived Behavior. Sustainability, 13(9), 4601. https://doi.org/10.3390/su13094601
      • [51] Salimi, A. R. (2019). EFFECTS OF ENVIRONMENTAL CONCERNS AND GREEN KNOWLEDGE ON GREEN PRODUCT CONSUMPTIONS WITH AN EMPHASIS ON MEDIATING ROLE OF PERCEIVED BEHAVIORAL CONTROL, PERCEIVED VALUE, ATTITUDE AND SUBJECTIVE NORM. International Transaction Journal of Engineering, Management, 651661. https://doi.org/10.14456/ITJEMAST.2019.6 1
      • [52] Schahn, J., & Holzer, E. (1990). Studies of Individual Environmental Concern: The Role of Knowledge, Gender, and Background Variables. Environment and Behavior, 22(6), 767–786. https://doi.org/10.1177/001391659022600 3
      • [53] Sousa, S., Correia, E., Viseu, C., & Larguinho, M. (2022). Analysing the Influence of Companies’ Green Communication in College Students’ Green Purchase Behaviour: An Application of the Extended Theory of Planned Behaviour Model. Administrative Sciences, 12(3), 80. https://doi.org/10.3390/admsci12030080
      • [54] Sreen, N., Purbey, S., & Sadarangani, P. (2018a). Impact of culture, behavior and gender on green purchase intention. Journal of Retailing and Consumer Services, 41, 177–189. https://doi.org/10.1016/j.jretconser.2017.1 2.002
      • [55] Sreen, N., Purbey, S., & Sadarangani, P. (2018b). Impact of culture, behavior and gender on green purchase intention. Journal of Retailing and Consumer Services, 41, 177–189. https://doi.org/10.1016/j.jretconser.2017.1 2.002
      • [56] Sundar, S. S. (2008). The MAIN model: A heuristic approach to understanding technology effects on credibility. MacArthur Foundation Digital Media and Learning Initiative Cambridge, MA
      • [57] Takala, M. (1991). Environmental Awareness and Human Activity. International Journal of Psychology, 26(5), 585–597. https://doi.org/10.1080/002075991082471 46
      • [58] Trivedi, R. H., Patel, J. D., & Acharya, N. (2018). Causality analysis of media influence on environmental attitude, intention and behaviors leading to green purchasing. Journal of Cleaner Production, 196, 11–22. https://doi.org/10.1016/j.jclepro.2018.06.0 24
      • [59] Vazifehdoust, H., Taleghani, M., Esmaeilpour, F., & Nazari, K. (2013). Purchasing green to become greener: Factors influence consumers’ green purchasing behavior. Management Science Letters, 3(9), 2489–2500
      • [60] Wang, B., Li, J., Sun, A., Wang, Y., & Wu, D. (2019). Residents’ Green Purchasing Intentions in a Developing-Country Context: Integrating PLS-SEM and MGA Methods. Sustainability, 12(1), 30. https://doi.org/10.3390/su12010030
      • [61] Wang, S.-T. (2014). Consumer characteristics and social influence factors on green purchasing intentions. Marketing Intelligence & Planning, 32(7), 738–753. https://doi.org/10.1108/MIP-12-2012-0146
      • [62] Weigel, R. H. (1983). Environmental attitudes and the prediction of behavior. Environmental Psychology: Directions and Perspectives, 257–287
      • [63] What is Influencer Marketing? | Read The Ultimate Guide. (2015, June 2). TapInfluence. https://www.tapinfluence.com/blog-what- is-influencer-marketing/

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