PHARMACEUTICAL BREAKTHROUGHS

ISSN NO : 2996-1157

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Umbilical Cord Stem Cell Stem Cell Therapy For Rare Genetic Disease Prader-Willi Syndrome

1 Cell Tech Stem Cell Centre Laboratory & Banking, Jakarta,Indonesia

Volume 1

Issue 1

Page: [8 - 16]

Published Online: November 10, 2023

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  • Abstract

    • This Abstract Summarises The Studies On The Use Of Umbilical Cord Stem Cells To Treat Prader-Willi Syn- Drome. Among The Various Stem Cells Found In The Umbilical Cord, Hematopoietic And Mesenchymal Stem Cells May Create Bioactive Molecules That Aid In Tissue Repair And Regeneration, Control Immunological Responses, And Give Birth To A Variety Of Cell Types. Because Of This, They Present A Feasible Option For Treating The Multidisciplinary Character Of PWS. Preclinical Research On PWS Animal Models Has Shown Promising Outcomes, With Umbilical Cord Stem Cell Transplantation Improving Metabolic Disorders, Hy- Pothalamic Function, And General Behavior. It Has Been Investigated If Immunological Regulation, Trophic Support, And Paracrine Signaling Are Among The Factors That Promote Stem Cell Therapeutic Potential. Several Clinical Studies Employing Umbilical Cord Stem Cells To Treat PWS Are Now Underway, And The Findings Should Aid In Assessing The Advantages And Disadvantages Of Using This Approach On Patients. The Preliminary Evidence Is Encouraging, Since Some Trial Participants Improved In Hyperphagia, Mus- Cular Tone, And Cognitive Ability. Although The Use Of Umbilical Cord Stem Cells As A PWS Treatment Has Shown Some Promise, Further Study Is Required To Determine Its Long-Term Safety, Optimal Dose, And Ongoing Effectiveness. A Variety Of Key Elements, Such As Ethical Issues, Regulatory Frameworks, And The Availability Of Standardized Stem Cell Products, Will Have A Considerable Impact On The Future Development Of This Treatment Technique. SD Is A Disease Known As A Neurodevelopmental Problem Represented Through Problems With Social Communication, Sensor Sensitivity, And Repetitive Behaviors. Despite Years Of Study, Therapy Options For Autism Spectrum Disorder (ASD) Remain Relatively Limited. As Regenerative Medicine Has Improved, Stem Cell Treatment Has Been Investigated As A Novel Thera- Peutic Option For The Underlying Neurological Disorders That Underpin ASD. The Development, Possible Methods, And Potential Uses Of Stem Cell Treatment For Autistic Children Are Discussed In This Article.

    Keywords: Prader-Willi Syndrome Umbilical Cord Stem Cells Stem Cell Therapy Genetic Disorder Multi-Systemic Improvements Preclinical Studies Clinical Trials Hypothalamic Function Behavioral Manifestations

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